Aktivitas Antimalaria Berbasis Penghambatan β-Hematin dalam Ekstrak Air Daun Jung Rahab (Baeckea frutecens L)
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چکیده
منابع مشابه
Antimalarial drugs inhibiting hemozoin (β-hematin) formation: A mechanistic update
Digestion of hemoglobin in the food vacuole of the malaria parasite produces very high quantities of redox active toxic free heme. Hemozoin (β-hematin) formation is a unique process adopted by Plasmodium sp. to detoxify free heme. Hemozoin formation is a validated target for most of the well-known existing antimalarial drugs and considered to be a suitable target to develop new antimalarials. H...
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Artemisin traditionally cleave the peroxide bond by Fe(II) found in heme proteins, thus generating toxic oxygen radicals. Synthetic peroxides, thus are proving to be useful substitutes for artemisinin. The first-generation ozonide OZ277, known as arterolane [1], has been found to inhibit the growth of chloroquine-resistant (K1) and chloroquine sensitive (NF54) parasite strains. In 2012, the com...
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ژورنال
عنوان ژورنال: Chimica et Natura Acta
سال: 2019
ISSN: 2541-2574,2355-0864
DOI: 10.24198/cna.v7.n1.19131